Stendra vs. Viagra: A Comprehensive Comparison

Introduction

Erectile dysfunction (ED) is a common condition affecting millions of men worldwide. In the United States alone, an estimated 15 to 30 million men experience ED. Two well-known medications prescribed for this condition are Stendra (avanafil) and Viagra (sildenafil). Both belong to a class of drugs called phosphodiesterase-5 inhibitors (PDE5 inhibitors), approved by the FDA for the treatment of ED. Other medications in this category include Cialis (tadalafil) and Levitra (vardenafil).

PDE5 inhibitors work by enhancing the effects of nitric oxide, a natural chemical the body produces to relax muscles in the penis. This increase in nitric oxide leads to improved blood flow, helping to achieve and maintain an erection. It’s important to note that these medications require sexual stimulation to be effective—they do not increase sexual desire on their own.

Key Differences Between Stendra and Viagra

While both Stendra and Viagra serve the same primary purpose, there are differences in their availability, onset of action, dosage, and side effect profiles.

Stendra (Avanafil)

• Availability: Stendra is available only as a brand-name medication. There is currently no generic version of avanafil.
• Dosage Forms: It comes in tablet form with doses of 50 mg, 100 mg, and 200 mg.
• Administration: Stendra can be taken as early as 15 minutes before sexual activity, especially at higher doses (100 mg or 200 mg). A 50 mg dose should be taken approximately 30 minutes prior.
• Frequency: Do not take more than one dose in a 24-hour period.
• Food Interaction: Can be taken with or without food.
• Efficacy: Effective in improving erectile function with a quick onset of action.

Viagra (Sildenafil)

• Availability: Viagra is available as both a brand-name and a generic medication.
• Dosage Forms: Available in tablet form with doses of 25 mg, 50 mg, and 100 mg.
• Administration: Should be taken approximately one hour before sexual activity but can be taken anywhere from 30 minutes to 4 hours prior.
• Frequency: Do not take more than one dose in a 24-hour period.
• Food Interaction: High-fat meals can delay its onset of action.
• Efficacy: Proven effective in numerous clinical trials over many years.

Conditions Treated

Both medications are primarily prescribed for:

• Erectile Dysfunction (ED): Difficulty achieving or maintaining an erection suitable for sexual activity.

They may also be used off-label for other conditions:

• Raynaud’s Phenomenon: A condition causing some areas of the body, like fingers and toes, to feel numb and cold.
• Pulmonary Arterial Hypertension (PAH): Sildenafil, the active ingredient in Viagra, is also prescribed under the brand name Revatio for treating PAH to improve exercise ability and delay clinical worsening.

Efficacy Comparison

Studies have shown that both Stendra and Viagra are effective in treating ED. The choice between them may depend on:

• Onset of Action: Stendra may work faster for some men, which can be advantageous for spontaneity.
• Side Effects: Both drugs have similar side effects, but individual tolerance can vary.
• Drug Interactions: Stendra may have fewer interactions with certain medications.
• Cost and Availability: Viagra is available in generic form, which can be more affordable.

A healthcare provider can help determine which medication is more suitable based on individual needs and health status.

Side Effects

Both medications can cause side effects, which are generally mild to moderate. Side effects can increase with higher doses.

Common Side Effects of Stendra

• Headache: 5.1-10.5%
• Flushing: 3.2-4.3%
• Nasal Congestion: 1.8-2.9%
• Back Pain: 1.1-3.2%
• Indigestion: 1-2%
• Dizziness: 1-2%
• Nausea: 1-2%

Common Side Effects of Viagra

• Headache: 16-28%
• Flushing: 10-19%
• Nasal Congestion: 4-9%
• Indigestion: 3-17%
• Back Pain: 3-4%
• Dizziness: 3-4%
• Nausea: 2-3%

Note: Percentages indicate the proportion of patients experiencing the side effect during clinical trials.

Drug Interactions

It’s crucial to be aware of potential drug interactions:

• Nitrates: Combining PDE5 inhibitors with nitrates (e.g., nitroglycerin) can cause a dangerous drop in blood pressure.
• Alpha-Blockers: Medications like tamsulosin used for prostate problems can also lower blood pressure; caution is advised.
• Antihypertensives: Blood pressure medications may have additive effects.
• Strong CYP3A4 Inhibitors: Drugs like ketoconazole, ritonavir, and certain antibiotics can increase levels of Stendra or Viagra in the blood, increasing side effects.
• Moderate CYP3A4 Inhibitors: Medications such as erythromycin and diltiazem require dosage adjustments.

Always inform your healthcare provider about all medications and supplements you’re taking.

Warnings and Precautions

• Cardiovascular Health: ED medications can strain the heart. Those with heart conditions should consult their doctor.
• Vision and Hearing Loss: Rare cases of sudden vision or hearing loss have been reported.
• Priapism: An erection lasting more than 4 hours requires immediate medical attention.
• Alcohol Consumption: Drinking alcohol can increase side effects like dizziness and lower blood pressure.
• Not for Use in Women: These medications are not approved for use in women, and safety during pregnancy is not established.
• Sexually Transmitted Infections: These drugs do not protect against STIs—practicing safe sex is important.

Cost and Insurance Coverage

• Stendra: As a brand-name drug without a generic version, Stendra can be expensive, and insurance coverage may vary.
• Viagra: With generic options available, Viagra (sildenafil) is generally more affordable. Insurance coverage varies by plan.

Using a prescription discount card or discussing options with your healthcare provider can help manage costs.

Frequently Asked Questions

Can I take Stendra or Viagra with alcohol?

• Moderate alcohol consumption may be acceptable, but excessive drinking can increase the risk of side effects and reduce the effectiveness of the medication.

How long does Stendra last?

• Stendra can work for up to six hours after taking it.

Is there a generic version of Stendra?

• As of now, there is no generic version of Stendra (avanafil).

Can women use these medications?

• These medications are not approved for use in women and should not be used during pregnancy or breastfeeding.

Can I take these medications with food?

• Stendra: Can be taken with or without food.
• Viagra: High-fat meals can delay its effectiveness, so it’s best to avoid heavy meals before taking it.

What should I do if I experience side effects?

• If side effects are mild, they may go away on their own. For severe or persistent side effects, contact your healthcare provider immediately.

Do I need a prescription for Stendra or Viagra?

• Yes, both medications require a prescription from a licensed healthcare provider.

Conclusion

Stendra and Viagra offer effective treatment options for men experiencing erectile dysfunction. While they function similarly, differences in onset of action, side effects, availability, and cost may influence the choice of medication. It’s essential to consult a healthcare provider to determine the most appropriate option based on individual health needs and medical history.

Remember: Always take medications as prescribed, be aware of potential interactions, and maintain open communication with your healthcare provider for the best outcomes.